Implementation in Lille of the mirror structure of LIMMS/CNRS-IIS (UMI 2820)


Seeding Microsystems in Medicine in Lille - European-Japanese Technologies against Cancer



The microsystems for biology and health, referred as bio-MEMS, experience an unprecedented development, especially in Japan. The technological level and maturity they demonstrate allow their integration in clinical trials protocols. Such microsystems are developed in LIMMS/CNRS-IIS, a joint international unit between CNRS and the Institute of Industrial Science of the University of Tokyo (IIS). The convergence of bioMEMS with a comprehensive research against Cancer open a promising scientific investigation domain, notably as the research against cancer pursued in Lille was endorsed by the National Cancer under the SIRIC ONCOLille program.



SMMiL-E relates to the setting-up and the realization of a comprehensive research program on bioMEMS against Cancer in a sustainable international high-level collaboration.

The project will synergize the bio-MEMS research from LIMMS/CNRS-IIS with the research against Cancer performed in Lille area under the SIRIC ONCOLille program. To reach its objectives, SMMiL-E encompasses the transfer in the Nord Pas-de-Calais region of Bio MEMS type micro technologies stemming from IIS. The bioMEMS technologies will be installed in a platform located in the mere hospital-university area, in order to be in close contact with medical teams with facilitated access to clinical research. The transferred technologies are positioned as a continuation of the advanced technologies of IEMN and would represent for IEMN an extension towards biology and medical applications.

SMMiL-E also aims to be a special observatory point from which it will be possible to measure the societal impact of these biotechnologies, considered as one of the six key enabling technologies in the Horizon 2020 European research framework. The interdisciplinary nature of the project will foster innovation, creation of intellectual property, and generate technology transfers towards related industrial partners. A training component is also part of the project, In the International Master of PRES Lille Nord de France context, joint careers in biophysics and bioengineering for health could be developed with the University of Tokyo, and include teaching-researchers mobility and students exchanges.



SMMiL-E project includes the setting-up of a new platform of the Institute of Industrial Science of the University of Tokyo (IIS) in connection with IEMN. The platform will be localized in the university-hospital area, to be nearest to medical teams.  First research location of IIS out of Japan, this implantation is backed by CNRS, the Centre Oscar Lambret and University of Sciences and Technology of Lille (USTL), as a UMI, International Join Unit, mirror site of LIMMS/CNRS-IIS UMI-2820.


Research activity

The scientific activities encompass bioMEMS research against Cancer – technology development and bio related experiments - as an original interdisciplinary approach to the SIRIC ONCO-Lille program. The projects aims to bridge fundamental and clinical research around 4 work packages related to the scale of transferred biotechnologies:

WP1: Bio molecular mechanisms of the tumor resistance to treatment (DNA degradation under therapeutic irradiations, Microtubules stabilization in chemotherapy, …)

WP2: Cellular evaluation and diagnosis: Stem cells and circulating tumor cells detection and sorting, study of cell senescence and tumor dormancy

WP3: Cells interaction and therapeutic targets: in vitro tumor angiogenesis, cellular mobility and metastatic processes

WP4: Biological adhesives and neo-tissues: cellular fibers and post-surgery recovery.

By means of an upstream research, this program targets more effective disease detection, a strengthened efficacy of therapy and post-treatment monitoring, for a better care to patient. 

------> More information about research




News. One publication in Nature Scientific report"A rapid and practical technique for real-time monitoring of biomolecular interactions using mechanical responses of macromolecules" by Mehmet Tarhan, Nicolas Lafitte, Yannick Tauran, Laurent Jalabert, Momoko Kumemura, Grégoire Perret, Beomjoon Kim, Anthony Coleman, Hiroyuki Fujita, and Dominique Collard 


News. SMMIL-E featured in the OncoLille Newsletter - May 2016. Link to OncoLille webpage



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Inauguration ceremony of the LIMMS mirror structure in Lille in June 2014




Thursday 17th of December, 2015 Workshop on BioMEMS and Cancer, at Institut de Biologie de Lille, Campus Pasteur