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LIMMS-CNRS / Institute of Industrial Science

The University of Tokyo


東京大学生産技術研究所 フランス国立科学研究センター





Welcome to LIMMS

Laboratory for Integrated Micro Mechatronic Systems

IIS building LIMMS is an international research unit on MEMS and NEMS (Micro- and Nano-Electro-Mechanical Systems) operated in joint names of France, CNRS - Département sciences et technologies de l'information et de l'ingénierie, and Japan, Institute of Indutrial Science (IIS), The University of Tokyo, and is located in Komaba Campus (II), Tokyo.


Our Research activities are concentrated on three main fields related to micro- and nano- technologies:


BIO-MEMS


NANOTECH


ADVANCED MEMS/NEMS

Scientific News

Year 2010

Journals

    1. P.E. Poleni, S. Ostrovidov, Y. Sakai and T. Fujii, A Practical Microfluidic Device for Synthesis of Purified Monodisperse Micro-Alginate Beads (MABs), The Online Journal of Scientific Poster, 2010, EP11066, Appeared in : Lab-on-a-Chip.com.
    2. F. Evenou, S. Couderc, B. Kim, T. Fujii, Y. Sakai, Microfibrillated cellulose sheets coating oxygen-permeable PDMS membranes induce rat hepatocyte 3D aggregation into stably-attached hemispheroids, Journal of Biomaterials Science: Polymer Edition, 2010.
    3. D. Bordel, D. Guimard, M. Rajesh, M. Nishioka, E. Augendre, L. Clavelier, and Y. Arakawa, Growth of InAs/GaAs quantum dots on germanium-on-insulator-on-silicon (GeOI) substrate with high optical quality at room temperature in the 1.3 μm band, Appl. Phys. Lett. 96, 043101 (2010); doi:10.1063/1.3292591
    4. D. Guimard, M. Ishida, D. Bordel, L. Li, M. Nishioka, Y. Tanaka, M. Ekawa, H. Sudo, T. Yamamoto, H. Kondo, M. Sugawara and Y. Arakawa, Ground state lasing at 1.30 µm from InAs/GaAs quantum dot lasers grown by metal–organic chemical vapor deposition, Nanotechnology 21 105604, 2010.
    5. Tarhan M.C.,Yokokawa R.,Bottier C.,Collard D. and Fujita H., A Nano-needle/microtubule composite gliding on a kinesin-coated surface for target Molecule Transport,
      Lab on a chip, 10(1): 86-91, 2010
    6. N. Pereira-Rodrigues, P-E. Poleni, D. Guimard, Y. Arakawa, Y. Sakai and T. Fujii. “Modulation of Hepatocarcinoma Cell Morphology and Activity by Parylene-C coating on PDMS”. PloS One, 2010 (Accepted for publication).
    7. L. Jalabert, M. Kumemura, C.Bottier, H. Fujita, “Nanoscale surface engineering of PDMS by embedding vertical nanosheets of materials.”, Microelectronics Engineering, 87 (2010) 1431–1434, [doi:10.1016/j.mee.2009.11.138]
    8. F. Evenou, T. Fujii, Y. Sakai, Spontaneous formation of stably-attached and 3D-organized hepatocyte aggregates on oxygen-permeable polydimethylsiloxane membranes having 3D microstructures, Biomedical Microdevices, 2010 (in press).
    9. F. Evenou, T. Fujii, Y. Sakai. Spontaneous Formation of Highly Functional Three-Dimensional Multilayer from Human Hepatoma Hep G2 Cells Cultured on an Oxygen-Permeable Polydimethylsiloxane Membrane. Tissue Engineering Part C: Methods 16(2):311-318 (2010)

    Conferences

      1. B. Daunay, L. Jalabert, M. Kumemura, H. Fujita, Experimental analysis of a closed/open microfluidic system for biological applications, Technical Meeting on Bio Micro Systems, IEE Japan, 2010, June 17-18, Tokyo
      2. N. Lafitte, M. Kumemura, D. Collard, S. Yoshizawa, D. Fourmy, L. Jalabert, S. Takeuchi, T. Fujii, H. Fujita, Direct bio-mechanical sensing analysis of enzymatic reactions on DNA by silicon nanotweezers, Technical Meeting on Micromachine and Sensor Systems, IEE Japan, 2010, June 17-18, Tokyo.
      3. L. Jalabert, S. Volz, L. Bouscayrol, T. Sato, T. Ishida, H. Fujita, Thermal conductance measurements in silicon nanowire using MEMS in TEM, Technical Meeting on Physical Sensors, IEE Japan, 2010, June 17-18, Tokyo.
      4. P-E. Poleni, S. Ostrovidov, Y. Sakai and T. Fujii, A Practical Microfluidic Device for Synthesis of Purified Monodisperse Micro-Alginate Beads (MABs), Proceedings of the 4th Annual Lab-on-a-Chip European Congress 2010, Dublin, Ireland, May 25-26 , 2010.
      5. L. Jalabert, S. Volz, T. Sato, T. Ishida, H. Fujita,
        Thermal Conductance Measurement of a Silicon Junction with Nanometer Scale Diameter, Presented (oral) at the 13th International Conference on Phonon Scattering in Condensed Matter - PHONON 2010 (Taipei - Taiwan - 18-23 April 2010).
      6. D. Guimard, D. Bordel, M. Ishida, M. Nishioka, Y. Wakayama, Y. Tanaka, H. Sudo, T. Yamamoto, H. Kondo, M. Sugawara, and Y. Arakawa, Growth of InAs/Sb:GaAs quantum dots by the antimony surfactant mediated metal organic chemical vapor deposition for laser fabrication in the 1.3 µm band, Proc. SPIE, Vol. 7610, 76100D (2010); doi:10.1117/12.842864.
      7. Grenier K.,Dubuc D.,P.-E. Poleni.,Kumemura M.,Fujii T.,Toshiyoshi H. and Fujita H., Resonant based microwave biosensor for biological cells discrimination,
        IEEE Radio and Wireless Symposium 2010, New Orleans, USA, 2010.
      8. L. Jalabert, T. Sato, M.Kumemura, D. Bolsee, C. Hermans, A. BenMoussa, H.Fujita, EMBEDDING VERTICAL NANOSHEETS OF METALS INTO PDMS WITH A REUSABLE TEMPLATE ENGINEERING, IEEE Int. Conf. on MEMS 2010, Hong Kong.
      9. M. Kumemura, D. Collard, S. Yoshizawa, D. Fourmy, N. Lafitte, L.Jalabert, S. Takeuchi, T. Fujii, H. Fujita, DIRECT BIO-MECHANICAL SENSING OF ENZYMATIC REACTION ON DNA BY SILICON NANOTWEEZERS, IEEE Int. Conf. on MEMS 2010, Hong Kong.

      Year 2009

      International Journals

        1. Tarhan M.C.,Yokokawa R.,Bottier C.,Collard D. and Fujita H., A Nano-needle/microtubule composite gliding on a kinesin-coated surface for target Molecule Transport,
          Lab on a chip, 10(1): 86-91, 2010
        2. Rousseau E.,Siria A.,Jourdan G.,Volz S.,Comin F.,Chevrier J. and Greffet J.-J., Radiative heat transfer at the nanoscale,
          Nature Photonics, 3: 514 - 517, 2009
        3. Arata H.,Gillot F.,Collard D. and Fujita H., Millisecond analysis of double stranded DNA with fluorescent intercalator by microthermocontrol-device,
          International Journal of Pure and Applied Analytical Chemistry (Talanta), 79(3): 963-966, 2009
        4. Ataka M.,Legrand B.,Buchaillot L.,Collard D. and Fujita H., Design, Fabrication, and Operation of Two-Dimensional Conveyance System With Ciliary Actuator Arrays,
          IEEE/ASME Transaction on Mechatronics, 14(1): 119-125, 2009
        5. Bottier C.,Fattaccioli J.,Tarhan M.C.,Yokokawa R.,Morin F.O.,Kim B.J.,Collard D. and Fujita H., Active transport of oil droplets along oriented microtubules by kinesin molecular motors,
          Lab on a chip, 9(12): 1694-1700, 2009
        6. Bozlar M.,He D.,Bai J.,Chalopin Y.,Mingo N. and Volz S., Carbon nanotube microarchitectures for enhanced thermal conduction at ultralow mass fraction in polymer composites,
          Advanced Materials, in press, 2009
        7. Chapuis Y.A.,Debray A.,Jalabert L. and Fujita H., Alternative approach in 3D MEMS-IC integration using fluidic self-assembly techniques,
          Journal of micromechanics and microengineering, 19(10): 1-9, 2009
        8. Collard D. and Fujita H., Mechanical characterization and modeling of chain molecules with MEMS tweezers,
          IEEJ Transactions on Electrical and Electronic Engineering, Invited, 2009
        9. Couderc S.,Blech V. and Kim B., New surface treatment and microscale/nanoscale surface patterning using electrostatically clamped stencil mask,
          Japanese Journal of Applied Physics, 48(9), 2009
        10. Couderc S.,Ducloux O.,Kim B.J. and Someya T., A mechanical switch device made of a polymide-coated microfibrillated cellulose sheet,
          Journal of micromechanics and microengineering, 19(5), 2009
        11. Dubuc D.,Grenier K.,Fujita H. and Toshiyoshi H., Plastic-based microfabrication of artificial dielectric for miniaturized microwave integrated circuits,
          Metamaterials, 3: 165-173, 2009
        12. Hajj B.,De Reguardati S.,Hugonin L.,Le Pioufle B.,Osaki T.,Suzuki H.,Takeuchi S.,Mojzisova H.,Chauvat D. and Zyss J., Electro-optical imaging microscopy of dye-doped artificial lipidic membranes,
          Biophysical Journal, 97(11): 2913-2921, 2009
        13. Hoel A.,Nishida S.,Kobayashi D.,Nishimori Y.,Rijk I. and Kawakatsu H., Building and testing of a liquid Atomic Force Microscope for imaging of biological samples,
          SEISAN-KENKYU, 61(2): 139-141, 2009
        14. Iino R.,Lam L.,Tabata K.,Rondelez Y. and Noji H., Single-molecule assay of biological reaction in femtoliter chamber array,
          Japanese Journal of Applied Physics, 48(8), 2009
        15. Ishida T.,Nakajima Y.,Endo J.,Collard D. and Fujita H., Real-time transmission electron microscope observation of gold nanoclusters diffusing into silicon at room temperature,
          Nanotechnology, 20(6), 2009
        16. Jalabert L.,Bottier C.,Kumemura M. and Fujita H., Embedded SiO2 nanosheets in PDMS using an alternative nanopatterning process,
          Journal of vacuum science and technology B, 27(6), 2009
        17. Levi T.,Tomas J.,Lewis N. and Fouillat P., A CMOS Resizing Methodology for Analog Circuits,
          IEEE Design & Test of Computers, 26(1): 78-86, 2009
        18. Mahamdi R.,Saci L.,Mansour F.,Temple-Boyer P.,Scheid E. and Jalabert L., Physicochemical Characterization of Annealed PolySi/NIDOS/SiO2 Structures,
          Spectroscopy Letters, 42(3): 167-170, 2009
        19. Montagne K.,Komori K.,Yang F.,Tatsuma T.,Fujii T and Sakai Y., A micropatterned cell array with an integrated oxygen-sensitive fluorescent membrane,
          Photochemical & Photobiological Sciences, 8(11): 1529-1533, 2009
        20. Nagai M. and Kumemura M.,Asai H., and Fujita H., Binding of artificial object to vorticella for a microsystem powered by a microorganism,
          e-Journal of surface science and nanotechnology, 7: 673-676, 2009
        21. Osaki T.,Suzuki H.,Le Pioufle B. and Takeuchi S., Multichannel simultaneous measurements of single-molecule translocation in alpha-hemolysin nanopore array,
          Analytical Chemistry, Online, 2009
        22. Ota S.,Yoshizawa S. and Takeuchi S., Microfluidic formation of monodisperse, cell-sized, and unilamellar vesicles,
          Angewandte Chemie, 48(35): 6533-6537, 2009
        23. Poleni P.E.,Ostrovidov S.,Sakai Y. and Fujii T., Maturation of Hep G2 cells is closely influenced by the microchannel height,
          International Journal of artificial organ, 32(7): 397-405, 2009

        2009 Papers - 2009 Conferences - Previous years

News

July 25th, 2010

BIO-NANO-ROBO Seminar Series Announcement
July 27th 2010 at PM 2:00
C-lounge, Building C, 2nd floor
IIS-University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8505.

Pr. Stephan DILHAIRE
Centre de Physique Moleculaire Optique et Hertzienne, Boredeaux, France

Title : When Photons listen to Phonons.
Abstract
How can light be used to generate and detect acoustic and thermal waves in solids? The principle of Picosecond Ultrasonics and Picosecond thermoreflectance is to use intense (100kW) and ultrashort (100fs) light train pulses as a hammer to produce a thermo acoustic perturbation in a nanomate- rial. A second light train pulses is used as a stroboscope to detect the surface motion or temperature with a sub picosecond time resolution. The thermal and acoustic spectrum can be monitored up to 2THz. The acoustic wavelength is in the order of nanometer. That allows this technique to be very well suited to micro and nano thermal physics, and nanomaterial physical properties measurement. The principle of Picosecond Ultrasonics and Picosecond thermoreflectance will be explained in simple words. Some applications to time resolved spectroscopy using a super continuum generated by a photonic crystal fiber will be presented. This kind of experiment can be used to generate and observe shear waves at picosecond time scale. This opens a new field for non-contact measurement, metrology and failure analysis in microelectronics. A few applications will be presented.
Download the Abstract

May 24th, 2010

Pr. A. Fuchs, President of CNRS France, will visit LIMMS on May 28th, 2010.

May 26th, 2010

BIO-NANO-ROBO Seminar Series Announcement
May 31st 2010 at PM 3:30
An301-302, Building A, 3rd Floor
IIS-University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8505.

Pr. Stanislav L.KARSTEN
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, USA

Title : ‘’Fishing expedition’’ for biomarkers and modifiers of human neurodegenerative diseases

Abstract :

Past decade was marked by rapid advances in genome sequencing combined with an unprecedented development of novel research approaches to study biological systems in their complexity. A vast amount of genomic information and new tools such as gene expression microarrays triggered the call for a broad experimental design that includes a prerequisite and more extensive ‘’hypothesis generation’’ steps logi- cally connected with follow-up functional studies. This approach lead to the development of a new field of research generally referred to as Functional Genomics. Our research applies the tools and techniques of functional genomics to the studies of human neurodegenerative diseases such as Alzheimer’s disease. It focuses on the generation of whole genome expression data in health and disease, and filtering these data using functional studies in vitro and in vivo towards the identification of novel biomarkers, disease modifiers and drug targets. In this presentation, several recently completed and ongoing projects will be described with a focus on identification and functional validation of puromycin sensitive aminopeptidase (PSA/NPEPPS), a novel neuroprotective factor that specifically acts on neurotoxic misfolded proteins. Special emphasis will be made on current methods and experimental challenges used in this work. Download the Abstract

May, 01st, 2010

Annoucement JFR 2010
The annual meeting of the French-speaking scientists in Japan will be held at the Maison Franco-Japonaise, Ebisu (Tokyo) on November 27th, 2010.
Researchers, students, officials, firms and organizations are welcome to attend. For more informations and inscriptions : [JFR2010].

March, 29th, 2010

Visit of LIMMS by a delegation from the French Ambassy in Japan, Madame Florence RIVIERE-BOURHIS (Conseiller pour la Science et la Technologie) and Monsieur Jacques MALEVAL (Conseiller spécial), together with Madame Natacha AVELINE (Directeur du bureau CNRS au Japon).

February, 4th, 2010

Steering Commitee
Every 4 years, LIMMS is evaluated by CNRS. At mid-term, a steering committee is organized in Tokyo.
Image:steering committee photo web001.jpg


BNR Seminars 2009

All the abstracts of BNR seminars organized in 2009 are available here.

Nov 14th, 2009

LIMMS was involved in a part of the organization of the Journée Francophone de la Recherche (JFR) 2009 at the Maison Franco-Japonaise of Tokyo (Ebisu), and presented several posters covering the 3 axis of our Research topics. The JFR is a one day seminar for the french-speaking community, whatever the nationality of participants, and is organized by the French Embassy, Sciencescope, CNRS North Asia, industries representatives CCE and CCIFJ and Japanese associations (ABSCIF, AFJEJ, ALFI, SFJTI). More informations are available on the JFR09 web page.

May 22nd 2009

Nanotweezers : LIMMS and IIS are cited in the "Techniques de l'ingenieur" (in french), and the "Journal of CNRS" (in french).
Techniques de l'ingenieur

le journal du CNRS/Faits marquants

March, 29th 2009

Le LIMMS Workshop was held in CNRS Paris, on March 10th. Almost 100 persons have attended this workshop, which was a full success for the organizers.
The aim of this workshop was both to present all the actual research topics performed by LIMMS members, and to offer a good opportunity for future CNRS researchers and post-doctorate candidates for LIMMS to meet all the host Professors.
Some pictures of the event are available on this link LIMMS WORKSHOP 2009.


previous events

Positions

  • to be announced : CNRS and JSPS-POST DOC POSITION AT LIMMS

Spring and Autumn JSPS Post doc Campain to be announced.


Conferences Schedule

  • MEMS 2008 : January, 13-17, 2008 (Tucson, Arizona, USA).
  • APCOT 2008 : Asia-Pacific Conference on Transducers and Micro-Nano Technology 2008

Old Conference Schedule



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