|Host Laboratory||KIM LAB.|
|Position in LIMMS||PhD Student|
|Main Research Topic in LIMMS|
Calix[n]arenes, Metallic nanoparticles, Biomolecules, Biosensing, Nanotweezers
|Contact||LIMMS/CNRS-IIS (UMI 2820)
Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan
Phone:+81 (0)3 5452 6036 / Fax:+81 (0)3 5452 6088
|yannick.tauran at univ-lyon1.fr|
|Download||Abstract2015_YTauran.pdf , Abstract2016
|Short resume :|
Research Projects in Limms
1- Micro and nano-systems for studying the bio recognition properties of hybrid metallic nanoparticles capped with calix[n]arenes
- Context :
- Calix[n]arenes are one of the most widely studied organic host classes. These bucket shaped molecules have gained tremendous importance for having interactions with biological molecules. And indeed their molecular recognition ability has been widely used for various applications such as diagnosis or medecine. Beside metallic nanoparticles are quite popular because of their unique optical and electronical properties. Their combination with calix[n]arenes is promising for bio-sensing and for their potent biomedical applications.
- Objectives :
- The assembly of hybrid metallic nanoparticles will be investigated over a wide range of biomolecules (DNA, protein, surfactant). Moreover devices fabricated from micro and nanotechnologies will be used to understand the mechanism of these supramolecular systems at nano scale.
- Methods :
- Recently we have developed very stable silver nanoparticles capped with different calix[n]arenes (fig. 1). Their complexation with biomolecules has been studied by conventional physico chemical analysis (Spectrophotometry, Fluorimetry, NMR, etc.) and by Silicon Nano Tweezer.
Fig.1 Schematic representation of the organization of para-sulphonatocalixarene on silver nanoparticles.
Fig.2 Schematic representation of the aggregation mechanism induced by 4 cytosines bridging the calix[n]arene silver nanoparticles (in grey).
- Results :
- Calix[n]arenes nanoparticles have been shown to possess antiviral activities  or to be used as biosensor . In the case of cytosine a possible mechanism at the molecular level can be derived from the solid-state structure of the cytosine: para-sulphonato-calixarene complex (fig. 2). Their mechanical effect on DNA strand has been recently investigated with Silicon Nano Tweezer. This is a great interest for elucidating their biochemistry on DNA .
This work is done in collaboration with the University of Lyon 1, LMI-UMR 5615.
- References :
-  Y. Tauran, C. Anjard, B-J. Kim, M. Rhimi and A. W. Coleman. Chem. Commun., 2014, 50, 11404-11406.
 Y. Tauran, B-J. Kim, A.W. Coleman. J. Nanosci. Nanotechnol., 2015. under press.
 Y.Tauran, M. Kumemura, N. Lafitte, R. Ueno, L. Jalabert, Y. Takayama, D. Collard, H. Fujita, A. W. Coleman and B-J. Kim, MicroTAS, Okinawa, JAPAN, 2012.
Main publication List (papers, conferences and patent)
- Y. Tauran, B.J. Kim, A.W. Coleman. Bio-applications of calix[n]arene capped silver nanoparticles. J. Nanosci. Nanotechnol., 2015. Accepted.
- Y. Tauran, C. Anjard, B. Kim, M. Rhimi and A. W. Coleman. Large supramolecular organic marcrocycles as inhibitors of endonuclease enzymes. Chem. Commun., 2014, 50, 11404-11406.
2013 and prior
- Y. Tauran, A. Brioude, A. W. Coleman, M. Rhimi, B. Kim. Review: Molecular recognition by gold, silver and copper nanoparticles. World Journal of Biological Chemistry. 2013, 4(3), 35-63.
- F. Perret, Y. Tauran, K. Suwinska, B.J. Kim, C. Chassain-Nely, M. Boulet, and A. W. Coleman, Molecular recognition and transport of active pharmaceutical ingredients on anionic calixarene-capped silver nanoparticles, Journal of Chemistry, Volume 2013 (2013), Article ID 191828.
- Y. Tauran, M. Rhimi, R. Ueno, M. Grosso, A. Brioude, E. Janneau, K. Suwinska, R. Kassab, P. Shahgaldian, A. Cumbo, B. Fenet, B.J. Kim, and A. W. Coleman, Cytosine: para-sulphonato-calixarene assemblies: in solution, in the solid-state and on the surface of hybrid silver nanoparticles, J. Incl. Phenom. Macrocycl. Chem., 2012, DOI: 10.1007/s10847-012-0235-4.
- Y. Tauran , A. Brioude , P. Shahgaldian , A. Cumbo , B. J. Kim , F. Perret , A. W. Coleman and I. Montasser, Calix-arene silver nanoparticles interactions with surfactants are charge, size and critical micellar concentration dependent, Chemical Communications, 2012, DOI:10.1039/C2CC34670B
- Y.Tauran, A. Brioude, B.J. Kim, F. Perret, A. W. Coleman and I. Montasser, Chem. Commun., 2012, 48, 9483-9485.
- Y.Tauran, M. A. Brioude, A. W. Coleman, Chem. Commun., 2011, 47, 10013-10015.
- Y. Tauran, R. Ueno, B. Kim, A.W. Coleman. Para-sulphonato-calixarene capped silver nanoparticles as complexing agents of Dopamine and Epinephrine. 3rd Euro-India International Conference on Nanomedicine and Tissue Engineering. Kottayam (India) August 9-11 2013. Poster.
- Y. Tauran, M. Kumemura, N. Lafitte, R. Ueno, L. Jalabert, Y. Takayama, D. Collard, H. Fujita, A. W. Coleman and B-J. Kim, ‘Mechanical effect of calix[n]arene capped silver nanoparticles on DNA measured with silicon nano tweezers’, MicroTAS, Okinawa, JAPAN, Oct. 28 – Nov. 1, 2012.
- Y. Tauran, R. Ueno, A.W. Coleman and B.J. Kim, Temperature effects on calixarene capped silver nanoparticle sensing of nucleotides, IEEE-NEMS 2012 (Kyoto).