Yannick TAURAN

Y.TAURAN.jpg Host Laboratory KIM LAB.
Position in LIMMS PhD Student
Main Research Topic in LIMMS

NANOTECH & Bio-MEMS - Calix[n]arenes in nano-biosystems

Keywords

Calix[n]arenes, Metallic nanoparticles, Biomolecules, Biosensing, Nanotweezers

Contact LIMMS/CNRS-IIS (UMI 2820)
Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan
Phone:+81 (0)3 5452 6036 / Fax:+81 (0)3 5452 6088
E-mail yannick.tauran at univ-lyon1.fr
Download icon_pdf.gifAbstract2015_YTauran.pdf , Abstract2016

Resume

 

Short resume :
2012-now Actual position
2008-2012 Here
2004-2008 Here
2001-2003 Here

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Research Projects in Limms

1-  Micro and nano-systems for studying the bio recognition properties of hybrid metallic nanoparticles capped with calix[n]arenes

Context :
Calix[n]arenes are one of the most widely studied organic host classes. These bucket shaped molecules have gained tremendous importance for having interactions with biological molecules. And indeed their molecular recognition ability has been widely used for various applications such as diagnosis or medecine. Beside metallic nanoparticles are quite popular because of their unique optical and electronical properties. Their combination with calix[n]arenes is promising for bio-sensing and for their potent biomedical applications.
Objectives : 
The assembly of hybrid metallic nanoparticles will be investigated over a wide range of biomolecules (DNA, protein, surfactant). Moreover devices fabricated from micro and nanotechnologies will be used to understand the mechanism of these supramolecular systems at nano scale.
Methods : 
Recently we have developed very stable silver nanoparticles capped with different calix[n]arenes (fig. 1). Their complexation with biomolecules has been studied by conventional physico chemical analysis (Spectrophotometry, Fluorimetry, NMR, etc.) and by Silicon Nano Tweezer.

tauran_Fig1.jpg

Fig.1 Schematic representation of the organization of para-sulphonatocalix[4]arene on silver nanoparticles.

tauran_Fig2.jpg

Fig.2 Schematic representation of the aggregation mechanism induced by 4 cytosines bridging the calix[n]arene silver nanoparticles (in grey).

Results : 
Calix[n]arenes nanoparticles have been shown to possess antiviral activities [1] or to be used as biosensor [2]. In the case of cytosine a possible mechanism at the molecular level can be derived from the solid-state structure of the cytosine: para-sulphonato-calix[4]arene complex (fig. 2). Their mechanical effect on DNA strand has been recently investigated with Silicon Nano Tweezer. This is a great interest for elucidating their biochemistry on DNA [3].

This work is done in collaboration with the University of Lyon 1, LMI-UMR 5615.


References : 
[1] Y. Tauran, C. Anjard, B-J. Kim, M. Rhimi and A. W. Coleman. Chem. Commun., 2014, 50, 11404-11406.

[2] Y. Tauran, B-J. Kim, A.W. Coleman. J. Nanosci. Nanotechnol., 2015. under press.

[3] Y.Tauran, M. Kumemura, N. Lafitte, R. Ueno, L. Jalabert, Y. Takayama, D. Collard, H. Fujita, A. W. Coleman and B-J. Kim, MicroTAS, Okinawa, JAPAN, 2012. 

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Main publication List (papers, conferences and patent)

2015

Journals
  1. Y. Tauran, B.J. Kim, A.W. Coleman. Bio-applications of calix[n]arene capped silver nanoparticles. J. Nanosci. Nanotechnol., 2015. Accepted.
Conferences

 

2014

Journals
  1. Y. Tauran, C. Anjard, B. Kim, M. Rhimi and A. W. Coleman. Large supramolecular organic marcrocycles as inhibitors of endonuclease enzymes. Chem. Commun., 2014, 50, 11404-11406.
Conferences

 

2013 and prior

Journals
  1. Y. Tauran, A. Brioude, A. W. Coleman, M. Rhimi, B. Kim. Review: Molecular recognition by gold, silver and copper nanoparticles. World Journal of Biological Chemistry. 2013, 4(3), 35-63.
  2. F. Perret, Y. Tauran, K. Suwinska, B.J. Kim, C. Chassain-Nely, M. Boulet, and A. W. Coleman, Molecular recognition and transport of active pharmaceutical ingredients on anionic calix[4]arene-capped silver nanoparticles, Journal of Chemistry, Volume 2013 (2013), Article ID 191828.
  3. Y. Tauran, M. Rhimi, R. Ueno, M. Grosso, A. Brioude, E. Janneau, K. Suwinska, R. Kassab, P. Shahgaldian, A. Cumbo, B. Fenet, B.J. Kim, and A. W. Coleman, Cytosine: para-sulphonato-calix[4]arene assemblies: in solution, in the solid-state and on the surface of hybrid silver nanoparticles, J. Incl. Phenom. Macrocycl. Chem., 2012, DOI: 10.1007/s10847-012-0235-4.
  4. Y. Tauran ,  A. Brioude ,  P. Shahgaldian ,  A. Cumbo ,  B. J. Kim ,  F. Perret ,  A. W. Coleman and I. Montasser, Calix-arene silver nanoparticles interactions with surfactants are charge, size and critical micellar concentration dependent, Chemical Communications, 2012, DOI:10.1039/C2CC34670B
  5. Y.Tauran, A. Brioude, B.J. Kim, F. Perret, A. W. Coleman and I. Montasser, Chem. Commun., 2012, 48, 9483-9485.
  6. Y.Tauran, M. A. Brioude, A. W. Coleman, Chem. Commun., 2011, 47, 10013-10015.
Conferences
  1. Y. Tauran, R. Ueno, B. Kim, A.W. Coleman. Para-sulphonato-calix[4]arene capped silver nanoparticles as complexing agents of Dopamine and Epinephrine. 3rd Euro-India International Conference on Nanomedicine and Tissue Engineering. Kottayam (India) August 9-11 2013. Poster.
  2. Y. Tauran, M. Kumemura, N. Lafitte, R. Ueno, L. Jalabert, Y. Takayama, D. Collard, H. Fujita, A. W. Coleman and B-J. Kim, ‘Mechanical effect of calix[n]arene capped silver nanoparticles on DNA measured with silicon nano tweezers’, MicroTAS, Okinawa, JAPAN, Oct. 28 – Nov. 1, 2012.
  3. Y. Tauran, R. Ueno, A.W. Coleman and B.J. Kim, Temperature effects on calixarene capped silver nanoparticle sensing of nucleotides, IEEE-NEMS 2012 (Kyoto).

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