Prof. Jean-Charles Duclos-Vallée (Centre Hépato-Biliaire, Paul-Brousse Hospital, France), 27th June 2017- Bw403

Prof. Jean-Charles Duclos-Vallée


From Centre Hépato-Biliaire, Paul-Brousse Hospital, France



Bioengineering and liver disorders : future applications

  Several priority themes of future clinical applications for the management of liver disorders will be discussed. The demand for liver repair and transplantation, and a shortage of available donors, necessitates the clinical need to develop innovative strategies for long term repair and regeneration of injured or diseases tissues and organs. In this aim, strategies for improvement of extracorporeal systems and engineering liver tissue constructs are necessary.

   Another important thematic domain is represented by liver-on-a-chip technology. Because drug-induced liver injury remains a cause of drug withdrawal from human clinical trials or the market place, the development of in vitro human liver models is crucial.

   Finally, because of the difficulty of understanding the pathogenesis, particularly in the interactome domain from in vivo studies, in vitro 3D and then 4D liver disorders models have to be created. For at least all these reasons, bioengineering will constitute an integral part of the support of patients with liver diseases in a next future.