JSPS Postdoctoral Fellowship on the project through the CNRS - Thin-Film-Transistor Sensor Array Platform for Analyzes of iPS Cells Culture (biotechnologies & electronics)

limit to candidate : 2019-09-02

Fields : biotechnologies and electronics 

Candidate must apply through ABG website, following this link for details and application : ABG 87029

Topic : Thin-Film-Transistor Sensor Array Platform for Analyzes of iPS Cells Culture

JSPS Postdoctoral Fellowship on the project through the CNRS

LIMMS (Laboratory for Integrated Micro Mechatronic Systems) is an international laboratory between the French CNRS (Centre National de la Recherche Scientifique) and Institute of Industrial Science (IIS), the University of Tokyo, located in Komaba, Tokyo. LIMMS has more than 24 years of experience in international cooperative research and has welcomed more than 240 researchers from France and Europe.

LIMMS opens a new postdoctoral position in the laboratory of Professor Agnès Tixier-Mita.

The LIMMS host professor laboratory’s main research activity concerns the investigation and the development of advanced integrated sensor array platforms for biological applications. Analyses of biological entities is usually performed optically. However, optical techniques are not portable and do not allow long term observation. Electrical analyses techniques propose another approach to biological questions, complimentary to the optical ones while overcoming these limitations. In particular, the host laboratory is pioneer in using Thin-Film-Transistors (TFT) technology for biological applications. TFT technology is the technology used in the fabrication of Liquid-Crystal-Displays (LCD). It is the only technology which allows to obtain transparent devices with a surface covered by a large array of independent micro-electrodes (pixels of the display), with a resolution which can reach few 10μm scale. Here, the micro-electrodes are used for sensing and manipulation of biological entities, mainly biological cells. That technology surpasses other technologies in term of sensing resolution and sensing area dimensions: large sensing area with high resolution are obtained to reach mesoscale sensing on biological cells culture, difficultly obtainable in other ways. In addition thanks to the device transparency, optical analyses can be combined to electrical analyses.

The laboratory’s research is very interdisciplinary and deals with electronics, micro-fluidics, micro-fabrication, biology and biochemistry. It has access to a clean-room for the microfabrication or devices post-processing, and a room called “Bio-room” for basic biological experiments on cells, as well as a complete environment for the interface and the sensing of the biological entities with electronic platforms. The host professor is the responsible for that “Bio-room”. Her research team is a small but dynamic group of Masters, PhD students and researchers. They are working on interfacing TFT platforms with neuron cells, cardiomyocyte cells or muscle cells for activity sensing, 2D cartography of the activity, and investigation of fundamental bio-medical questions to which electrical sensing can bring new information. Electrical monitoring cells culture is also under development by means of impedance sensing. Other topics include electrical manipulation of cells by dielectrophoresis for cells patterning, and the development of biosensors array of bio-molecules. Fundamental bio-medical questions are investigated in collaboration with expert biological or medical laboratories. Actually, iPS cells, differentiable in neurons, are among the cells of interest of a collaborator of the LIMMS host professor, and are the target of this project.

more details here